Plants with milky sap are sometimes regarded with suspicion – giant hogweed and oleander come to mind – and rightly so.

Plants with Milky Sap

A lot of them have toxic chemicals that can irritate upon contact. Let’s look at the plants that we commonly encounter in order to identify if they’re safe for us or not.

A Variety of Plants That Secrete Milky Sap

1. Manchineel Tree

Poisonous Manchineel Tree

USDA zone
  • 10 to 12
  • Sample cities: Naples, Florida; Victorville, California
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Small to medium sized tree about 40 feet tall
  • Glossy dark green leaves
  • Small fruits similar to apples or guavas in appearance

When parts of the tree are cut, they exude a milky white liquid. All parts of the tree contain various toxic compounds that can cause severe skin irritation, as well as other health issues, especially when touched or ingested.

The sap is particularly dangerous because skin contact can cause severe blisters and burns. Worse, the toxins can even cause death.

2. Giant Hogweed

Towering Giant Hogweed Plant

USDA zone
  • 5 to 7
  • Sample cities: Des Moines, Iowa; Columbia, Missouri
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Grows up to 14 feet tall
  • Stems with dark red or purple blotches and bristly white hairs
  • When cut, milky sap can burn skin

Found in various regions in Europe and North America, the giant hogweed is an invasive plant species. While it is a member of the carrot family, it is not as welcome.

This is due to the strong toxins that are found in the plant, which can irritate humans and animals alike. All parts of this plant are toxic, with the sap being the worst element since it causes severe skin and eye issues.

3. Belladonna

Deadly Belladonna Nightshade

USDA zone
  • 6 to 9
  • Sample cities: St. Louis, Missouri; Lebanon, Pennsylvania
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Grows up to 4 feet tall
  • Dark green leaves can reach 6 inches long
  • Large pink or purple bell-shaped flowers give way to shiny black berries

Native to Europe, North Africa, and Western Asia, it is usually found only in carefully curated cultivation in botanical gardens and private collections in North America.

The plant contains a deadly cocktail of toxic alkaloids that cause a wide range of symptoms. In severe cases, the belladonna can cause death in humans.

4. Calotropis

Resilient Calotropis Milkweed

USDA zone
  • 10 to 11
  • Sample cities: Coral Gables, Florida; Honolulu, Hawaii
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Grows up to 10 to 15 feet tall
  • Large, thick, fleshy leaves that are dark on top and paler under
  • Large trumpet-shaped white or pink flowers with a very unpleasant smell

The milky sap of this plant is highly toxic. The sap is excreted by parts of the plant when they are cut or plucked away.

It has been known to cause diarrhea, convulsions, and slow heartbeats. In extreme cases, the sap can even cause death.

5. Euphorbia

Versatile Euphorbia Succulent

USDA zone
  • 5 to 11
  • Sample cities: Little Rock, Arkansas; Griffin, Georgia 
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Small blossoms surrounded by large and colorful bracts in yellow, pink, or red
  • Cultivated as landscape plants in many gardens
  • Adaptive enough to grow in deserts, temperate regions, and tropical rainforests

The euphorbia milky sap comes out only when parts of the plant are cut or damaged. In extreme situations, getting euphorbia sap in your eye can cause blindness.

When handling the plants as ornamentals, always wear protective clothing, such as gloves, goggles, and face masks.

6. Oleander

Toxic Oleander Bush

USDA zone
  • 8 to 10
  • Sample cities: Houston, Texas; Fort Pierce, Florida
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Cultivated as landscape plants in many gardens
  • Can become invasive in many parts of the United States
  • Can grow up to 20 feet with dark glossy green leaves and large flower clusters

All parts of the oleander plant are highly toxic. Its sap can cause skin irritation. Ingesting parts of the plant can cause diarrhea, vomiting, and irregular heartbeat at its most mild.

The worst-case scenario for ingesting oleander parts is death. When pruning this plant, always wear protective clothing and gear.

7. Weeping Fig

Graceful Weeping Fig Tree

USDA zone
  • 10 to 12
  • Sample cities: Coral Gables, Florida; Honolulu, Hawaii 
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Cultivated as landscape plants in many gardens
  • Can grow up to 30 feet with glossy green leaves with a graceful growing habit
  • Typically with a spread similar to its height

The leaf and twigs of the weeping fig can be toxic for animals as they contain oxalate crystals. The symptoms include diarrhea and vomiting. Plus, the milky excretions from the cut or broken parts of the tree can cause inflammation and skin irritations.

Similar to reactions to the milky sap of rubber trees, the symptoms may get stronger when the skin gets exposed to sunlight.

8. Papaya

Nutritious Papaya Fruit

USDA zone
  • 9 to 11
  • Sample cities: Victorville, California; Mazatlan, Mexico
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Grown mostly for its fruit rather than its appearance
  • Leaves are broad, palmate, and lobed
  • Grows from 6 to 20 feet tall

The milky secretions from the papaya plant and fruit can cause skin irritations. Depending on the skin sensitivity, the reaction can range from mild to severe.

Additionally, the edible seeds contain traces of cyanide. While harmless in small amounts, large amounts can lead to upset stomachs and other worrying symptoms.

9. Frangipani

Fragrant Frangipani Plumeria

USDA zone
  • 9 to 11
  • Sample cities: Brownsville, Texas; Fort Pierce, Florida; 
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Cultivated as landscape plants in many gardens
  • Large glossy green leaves are elongated
  • Flowers are often five-petalled in varying colors, shapes, sizes, and fragrances

The sap excreted by the frangipani can be irritating when in contact with the skin. Depending on the individual’s sensitivity, the reaction can range from mild itching to skin dermatitis. All parts of the frangipani are considered toxic.

Ingesting the parts or sap can induce nausea, vomiting, and diarrhea. Its scent can prove tempting to children or pets, so keep this plant away from them.

10. Blue Lily

Majestic Blue Lily Flower

USDA zone
  • 8 to 11
  • Sample cities: Miami, Florida; Honolulu, Hawaii
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Long evergreen foliage with stems that reach over 3 feet high
  • White, blue, or purple flowers are borne in an umbel
  • Roots can be so powerful that they are known to break through concrete

Due to its beauty, many homeowners fail to remember that the white liquid in the plant stem can be irritating. When in contact with the skin, the individual can experience irritations or even inflammations.

Additionally, the sap can cause the eyes to experience burning sensations. It is most toxic when ingested as it can cause severe mouth ulcers, vomiting, and diarrhea.

11. Small Periwinkle

Delicate Small Periwinkle Bloom

USDA zone
  • 4 to 8
  • Sample cities: Tifton, Georgia; Dallas, Texas
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Simple glossy green leaves
  • White, purplish-blue, or pinkish-purple flowers 
  • Cultivated for its beauty

All parts of the plant are toxic, including the sap. Unlike the campanula white sap, the excreted sap can be harmful when taken in large doses.

In the event that enough has been ingested, symptoms can include nerve problems, hearing difficulties, and hallucinations. It can be tempting for children and pets, so keep them away from this plant.

12. Pain Bush

Medicinal Pain Bush Plant

USDA zone
  • 9 to 11
  • Sample cities: Houston, Texas; St. Augustine, Florida
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Small tree or large shrub
  • Leaf clusters of three
  • Low-growing habit

This plant is known as the African version of the poisonous ivy. However, it is not related as it belongs to another family altogether.

Despite this, this plant has been known to cause the same effects when its sap comes into contact with humans. This can result in muscle weakness, painful blisters, and even blindness.

13. Belladonna Lily

Striking Belladonna Lily Flower

USDA zone
  • 4 to 10
  • Sample cities: Minneapolis/St.Paul, Columbia, Missouri
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Simple glossy green leaves
  • White, purplish-blue, or pinkish-purple flowers 
  • Cultivated for its beauty

Its botanical name is Amaryllis belladonna, although it is not related to the belladonna plant. It is a toxic lily that looks highly attractive due to its colorful flowers.

However, its sap has been found to be severely toxic to humans. Symptoms include vomiting, diarrhea, drooling, heart failure, and it can even cause paralysis or death.

14. Pencil Cactus

Unique Pencil Cactus Plant

USDA zone
  • 9 to 11
  • Sample cities: Houston, Texas; St. Augustine, Florida
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Can grow up to 40 feet when fully mature
  • Can look like a shrub or tree without any leaves at all
  • Succulent-like branches

Sometimes called the milk bush or the firestick plant, the pencil cactus belongs to the Euphorbia family. However, it is distinct in its appearance in that it does not possess any foliage at all.

The whole plant looks like it is made up of green branches. When these are broken, the plant excretes an irritating sap that can even cause burns.

15. Common Milkweed

Beneficial Common Milkweed Herb

USDA zone
  • 5 to 10
  • Sample cities: Des Moines, Iowa; Victorville, California
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Leaves are broad and thick
  • Flowers are light pink or violet, arranged similarly to spherical umbels
  • Fruits are large, rough, bumpy, downy, and shaped like spindles

While it is favored by many gardeners for its ability to attract pollinators, it’s not exactly harmless. When parts of the plant are damaged or broken, they secrete a thick sap that can irritate humans upon contact.

Symptoms include nausea, diarrhea, weakness, and even death when ingested in large amounts.

16. Wild Lettuce

Soothing Wild Lettuce Leaf

USDA zone
  • 6 to 9
  • Sample cities: McMinnville, Tennessee; Branson, Missouri
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Small to medium in size
  • The base is a thick, flowering stalk
  • Leaves are long, oblong, and smooth with a clear central vein

Its botanical name is Lactuca virosa. Despite being a distant cousin of cultivated lettuce, this plant is not as beneficial to humans.

When broken or damaged, parts of the wild lettuce can excrete a sap that has known sedative effects. When ingested in large amounts, the plant can cause humans to experience hypnotic, antispasmodic, and narcotic effects.

17. Balloon Flower

Beautiful Balloon Flower Blossom

USDA zone
  • 4 to 8
  • Sample cities: Minneapolis/St.Paul, Minnesota; Lewistown, Montana
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Plant grows up to 2 to 2.5 feet tall
  • Unique, star-like purplish-blue flowers
  • Flowers are thick, rubbery, and up to 3 inches across

While its sap is not exactly poisonous, it can cause varying levels of discomfort in humans. These include stomach cramps, vomiting, and severe diarrhea.

This plant grows mostly in the wild, although homeowners are finding the balloon flower to be a popular garden plant. Keep this plant away from curious children and pets.

18. Arkansas Blue Star

Vibrant Arkansas Blue Star Plant

USDA zone
  • 5 to 9
  • Sample cities: McMinnville, Tennessee; Fort Pierce, Florida
Growing season
  • Spring
  • Summer
Growing conditions
  • Moist, well-draining soil
  • Full sun
Distinguishing Characteristics
  • Can grow up to 3 feet tall
  • Stems come out from a crown and can spread 4 feet in mature specimens
  • Leaves are linear, similar to grass in appearance

This plant is a member of the dogbane family, which is known to have toxic or poisonous properties. In this case, the Arkansas blue star secretes a sap that is highly irritating to human skin.

It can cause irritation, such as rashes and blisters, depending on the skin sensitivity. When pruning this plant, always wear protective clothing and gear.

Conclusion

It can be difficult to remember that beautiful plants can be toxic, too.

Here are some things you’ll need to keep in mind:

  • Milky secretions are one of the ways plants defend or heal themselves from damage.
  • Always wear protective clothing and gear when caring for plants with toxic parts or saps.
  • When in doubt, always err on the side of caution and avoid touching plants that may be toxic.

If you ever encounter a plant with toxic milky sap found on our list, it’s best to admire it from a distance. 

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